Floris P J G Lafeber Selected Research

Proteins (Proteins, Gene)

1/2021	Dorsal Root Ganglia Macrophages Maintain Osteoarthritis Pain.
1/2020	Comprehensive exploratory autoantibody profiling in patients with early rheumatoid arthritis treated with methotrexate or tocilizumab.
1/2019	Adding baseline protein biomarkers to clinical predictors does not enhance prediction of treatment response to a methotrexate strategy in early rheumatoid arthritis.
11/2018	Explorative analyses of protein biomarkers in patients with early rheumatoid arthritis achieving sustained drug-free remission after treatment with tocilizumab- or methotrexate-based strategies: from transcriptomics to proteomics.
1/2016	IL4-10 Fusion Protein Is a Novel Drug to Treat Persistent Inflammatory Pain.
11/2007	Profiling of endogenous peptides in human synovial fluid by NanoLC-MS: method validation and peptide identification.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Floris P J G Lafeber Research Topics

Disease

37	Rheumatoid Arthritis 11/2022 - 06/2002
25	Osteoarthritis 12/2023 - 01/2002
20	Inflammation (Inflammations) 11/2020 - 07/2002
12	Joint Diseases (Joint Disease) 01/2024 - 11/2007
11	Pain (Aches) 12/2023 - 01/2011
7	Knee Osteoarthritis 12/2023 - 07/2017
7	Arthritis (Polyarthritis) 12/2020 - 11/2005
6	Hemophilia A (Haemophilia) 01/2024 - 02/2013
4	Synovitis 11/2020 - 06/2005
4	Autoimmune Diseases (Autoimmune Disease) 01/2016 - 10/2006
3	Experimental Arthritis 01/2015 - 09/2010
3	Necrosis 12/2012 - 05/2007
2	Infections 01/2021 - 11/2020
2	Wounds and Injuries (Trauma) 11/2020 - 01/2017
2	Hemorrhage 01/2017 - 02/2003
2	Rheumatic Diseases (Rheumatism) 08/2014 - 01/2008
1	Hypersensitivity (Allergy) 12/2023
1	Psoriatic Arthritis 10/2022
1	Disease Progression 01/2020
1	Fatigue 12/2017
1	Chronic Disease (Chronic Diseases) 12/2017
1	Aneurysm (Aneurysms) 01/2017
1	Vascular Remodeling 01/2017
1	Neuralgia (Stump Neuralgia) 01/2016
1	Chronic Pain 01/2016
1	Hyperalgesia 01/2016
1	Hemochromatosis (Bronze Diabetes) 08/2015

Drug/Important Bio-Agent (IBA)

17	Biomarkers (Surrogate Marker)IBA 11/2023 - 11/2007
14	Methotrexate (Mexate)FDA LinkGeneric 01/2021 - 03/2012
12	CytokinesIBA 01/2021 - 07/2002
10	Interleukin-7 (Interleukin 7)IBA 01/2015 - 06/2005
6	Proteins (Proteins, Gene)FDA Link 01/2021 - 11/2007
6	tocilizumab (atlizumab)FDA Link 01/2021 - 12/2017
5	IronIBA 01/2024 - 03/2014
4	Collagen Type II (Type II Collagen)IBA 12/2021 - 01/2009
4	Antirheumatic Agents (DMARD)IBA 01/2021 - 01/2013
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2018 - 05/2007
4	GlucocorticoidsIBA 04/2017 - 11/2005
4	Interleukin-10 (Interleukin 10)IBA 01/2016 - 04/2003
4	Thymic Stromal LymphopoietinIBA 01/2016 - 05/2014
4	Proteoglycans (Proteoglycan)IBA 01/2015 - 02/2003
4	InterleukinsIBA 01/2015 - 05/2007
3	AntigensIBA 01/2020 - 07/2008
3	Interleukin-4 (Interleukin 4)IBA 01/2016 - 12/2012
3	Prednisone (Sone)FDA LinkGeneric 10/2015 - 03/2012
3	CollagenIBA 01/2013 - 01/2002
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 11/2020
2	ametantrone (HAQ)IBA 12/2020 - 09/2013
2	Folic Acid (Vitamin M)FDA LinkGeneric 12/2020 - 01/2018
2	Peptides (Polypeptides)IBA 01/2019 - 11/2007
2	3-benzoyl dopamine (MBDA)IBA 11/2018 - 10/2012
2	LipidsIBA 12/2016 - 09/2016
2	Cartilage Oligomeric Matrix ProteinIBA 01/2013 - 01/2009
2	InterferonsIBA 12/2012 - 10/2006
2	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2011 - 01/2006
2	Immunoglobulin G (IgG)IBA 12/2004 - 05/2003
2	Advanced Glycation End ProductsIBA 04/2004 - 01/2002
1	Transferrin (beta 2 Transferrin)IBA 01/2024
1	Heme (Haem)IBA 01/2024
1	MyostatinIBA 12/2023
1	LigandsIBA 12/2023
1	P-30 composite resin (P 30)IBA 12/2023
1	5- chloro- 3- tert- butyl- 2'- chloro- 4'- nitrosalicylanilide (S 13)IBA 12/2023
1	amsonic acid (DAS)IBA 11/2022
1	5-(tetradecyloxy)-2-furancarboxylic acid (TOFA)IBA 10/2022
1	tofacitinibIBA 10/2022
1	Immunologic Factors (Immunomodulators)IBA 10/2022
1	IL4-IL10 fusion proteinIBA 01/2021
1	Ointments (Pastes)IBA 11/2020
1	cadexomer iodineIBA 11/2020
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 11/2020
1	Dinoprostone (PGE2)FDA Link 11/2020
1	Analgesics (Analgesic Drugs)IBA 11/2020
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 11/2020
1	Interleukin-6 Receptors (Interleukin 6 Receptor)IBA 01/2020
1	Rheumatoid FactorIBA 01/2020
1	AutoantibodiesIBA 01/2020
1	Rituximab (Mabthera)FDA Link 11/2018
1	AlbuminsIBA 01/2018
1	1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA 01/2018
1	Blood Coagulation Factors (Coagulation Factor)IBA 01/2017
1	Peptide Hydrolases (Proteases)FDA Link 01/2017
1	Matrix Metalloproteinases (MMPs)IBA 01/2017
1	Cathepsin BIBA 01/2017
1	Hyaluronic Acid (Hyaluronan)IBA 05/2016
1	MicroRNAs (MicroRNA)IBA 01/2016

Therapy/Procedure

11	Therapeutics 07/2021 - 11/2005
4	Knee Replacement Arthroplasty (Total Knee Replacement) 12/2023 - 07/2017
3	Spinal Injections 12/2023 - 12/2019
3	Intra-Articular Injections 02/2013 - 09/2012
2	Osteotomy 01/2021 - 01/2021
2	Aftercare (After-Treatment) 11/2018 - 10/2018
2	Injections 01/2016 - 09/2012
2	Bed Rest (Bedrest) 09/2012 - 11/2005
1	Ambulatory Care (Outpatient Care) 11/2023
1	CARE protocol 11/2020
1	Drug Therapy (Chemotherapy) 01/2020
1	Arthroplasty 01/2020
1	Conservative Treatment 07/2017
1	Orthopedic Procedures 01/2017